冠状动脉病变严重程度、病变位置及冠心病介入治疗
摘要:探讨冠状动脉病变严重程度、病变位置及冠心病介入治疗对QT离散度(QTd)及校正QT离散度(QTcd)的影响。入选159例已行冠脉造影术且心电图及临床资料完整的病例,按如下进行分组: (1)按病变狭窄程度分组:①无狭窄组,冠脉造影示病变狭窄<50%,为31例;②轻度狭窄组,冠脉造影示病变狭窄≥50%且<70%,为54例;③重度狭窄组,冠脉造影示病变狭窄≥70%,为74例。(2)根据病变位置分组:①前降支组,为45例;②回旋支组,为37例;③右冠脉组,为46例。(3)根据介入治疗前后分组为:①术前组,为99例;②术后组,为99例。观察冠状动脉病变狭窄程度、病变位置及介入治疗对QTd及QTcd的影响。结果:冠脉狭窄≥70%对QTd及QTcd影响明显,p<0.05,而冠脉狭窄<70%对QTd及QTcd无明显影响,p>0.05;冠脉病变所处位置对QTd及QTcd无明显影响,p>0.05;介入治疗前后QTd及QTcd变化明显,p<0.05,介入治疗术后与无狭窄组相比,QTd及QTcd无明显差异,p>0.05。结论:冠脉病变所出位置对QTd及QTcd无影响,病变严重程度及介入治疗对QTd及QTcd影响明显。
关键词:冠状动脉造影 心电图 QT离散度
YUAN Yi-qiang LIU Huai-ling MA Ye-xin,et al.The Influence of The Stenoses、Location and Intervention of Coronary Artery Disease (CAD)on QT Dispersion(QTd)and corrected QTd(QTcd).To investigate the influence of stenosis、location and intervention of CAD on QTd and QTcd.159 patients,who were performed coronary angiography,with complete clinical and ECG data,were divided into groups as follow:(1)Groups divivded into in accord with stenoses:①No stenoses group,stenoses <50%,31 cases;②Light stenoses goup,stenoses≥50% and <70%,54 cases;③Severe stenoses group,stenoses≥70%,74 cases.(2) Groups divided into in accord with the location of CAD:①Left anterior descending group,45 cases;②Left circumflex group,37 group;③Right coronary group,46 cases.(3)Groups divided into in accord with intervention time:①Before intervention group,99cases;②After intervention group,99 cases.Investigated the influence of stenoses、 location and intervention of CAD on QTd and QTcd.Results:Severe stenoses(≥70%)significantly influenced QTd and QTcd,p<0.05,and light stenoses(≥50% and <70%)didn’t significantly influence QTd and QTcd,p>0.05;The location of CAD didn’t significantly influence QTd and QTcd,p>0.05. Intervention significantly influenced QTd and QTcd,contrasted before with after operation,p<0.05,and contrasted after operation with no stenoses group,p>0.05.Conclusion:Severe stenoses and intervention significantly influenced QTd and QTcd,and the location hardly influenced QTd and QTcd.
Key words Coronary Angiography Electrocardiogram QT Dispersion
QT离散度(QTd)是近年来发展起来的一项预测心脏复极同步的新指标。其定义为常规12导联心电图中最长QT与最短QT之差,可以较好的预测心律失常和猝死的发生。本研究旨在探讨冠状动脉病变严重程度、病变位置及介入治疗对QTd及校正QTd(QTcd)的影响。
1 资料与方法
1.1 研究对象及分组 选择完成冠状动脉造影且心电图及临床资料完整病例159例。排除心肌梗死、充血性心力衰竭、瓣膜性心脏病、左心室肥厚、高血压3级、心房纤颤、束支传导阻滞、预激综合症及使用I、III类抗心律失常药物的患者。冠脉造影提示的双支、三支病变病例亦排除在外。上述研究对象按如下方案进行分组:根据冠脉造影病变狭窄程度分组:①冠脉无狭窄组,病变狭窄<50%,为31例;②冠脉轻度狭窄组,病变狭窄≥50%且<70%,为54例;③冠脉重度狭窄组,病变狭窄≥70%,为74例。根据病变位置分为三组:①前降支组,为45例;②回旋支组,为37例;③右冠组,为46组。根据介入治疗术前、术后分组:①术前组,为99例;②术后组,为99例。上述各组性别、年龄无明显差异。
《冠状动脉病变严重程度、病变位置及冠心病介入治疗》
1.2冠脉造影及介入治疗 采用Judkin`s法进行选择性左、右冠状动脉造影,进行多体位投照。所入选的病例均为单支病变,即左前降支、左回旋支或右冠的任一主支或主要分支。对病变狭窄≥70%病例均行介入治疗;病变狭窄≥50%且<70%的病例,若有典型心绞痛发生及心绞痛发作时心电图动态变化亦行介入治疗。所有病例均采用股动脉途径,且全部植入冠状动脉支架。
QT间期的测量及QTd、QTcd的计算 心电图选取常规12导联,且为同步记录,纸速50mm/s,电压1.0mv/cm。当