E1A基因抗癌作用及其在头颈肿瘤治疗中的应用
nbsp;E1
A gene.Oncogene,1996,13:1083-1092.
11 Chen MJ,Holskin B,Strickler J, et al.Induction by E1A oncogene expr
ession of cellular susceptibility to lysis by TNF.Nature,1987,330:581-5
84.
12 Steeg PS,Bevilacqa G,Pozzatti R, et al.Altered expression of nm23,a
gene associated with low tumor metastatic potential,during adenovirus
2 E1A inhibition of experimental metastasis.Cancer Res,1988,48:6550-655
4.
13 Shao RP,Karunagaran D,Zhou BH, et al.Inhibition of nuclear factor-K
B activity is involved in E1A-mediated sensitization ofradiation-induce
d apoptosis.J Biol Chem,1997,272:32739-32742.
14 Xia W,Lan YK,Zhang HZ, et al.Strong correlation between c-erbB-2 ov
erexpression and overall survival of patients with oral squamous cell c
arcinoma.Clin Cancer Res,1997,3:3-9.
15 Hou L,Shi D,Tu SM, et al.Oral cancer progression and c-erbB-2/neu p
roto-oncogene expression.Cancer Letters,1992,65:215-220.
16 Beckhardt RN,Kiyokawa N,Xi L, et al.HER-2/neu oncogene characteriza
tion in head and neck squamous cell carcinoma.Arch Otolaryngol Head Nec
k Surg, 1995, 121:1265-1270.
17 Karja V,Syrjanen S,Kataja V, et al.c-erbB-2 oncogene expression in
salivary land tumors.ORL J Otorhinolaryngol Relat Spec, 1994,56:206-212
.
18 王琪，韩德民，刘鋋，等.头颈部肿瘤的P53基因研究进展.国外医学耳鼻咽喉
科学分册,1996,20：4-7.
19 Liu M,Lawson G,Delos M, et al. Expression of E-cadherin adhesion mo
lecule in vocal cord carcinomas.&nbs
-421.
20 王强，郭敏，孙连玉.nm23-H1基因在喉癌组织中表达的研究.中华耳鼻咽喉科
杂志,1996,31：198-200.
21 Yu D,Matin A,Xia W, et al.Liposome-mediated in vivo E1A gene tranfe
r suppressed dissemination of ovarian cancer cells that overexpress HER
-2/neu.Oncogene, 1995,11:1383-1388.
22 Ueno NT,Hung MC,Zhang S, et al.Phase I E1A gene therapy in patients
with advanced breast and ovarian cancer.Proc AACR,1998,39:360-364.
23 Yoo GH,Ensley J,Jacobs J, et al.Intratumoral E1A gene therapy for p
atients with unresectable and recurrent head and neck cancer.Proc AACR,
1998,39:322-324.
24 Kirn D,Nemunaitis J,Ganly I, et al. A phase Ⅱ trial of intratumora
l injection with an E1B-deleted adenovirus, ONYX-015,in patients with r
ecurrent,refractory head and neck cancer.Proc ASCO,1998,17:391-394.
《E1A基因抗癌作用及其在头颈肿瘤治疗中的应用(第3页)》
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A gene.Oncogene,1996,13:1083-1092.
11 Chen MJ,Holskin B,Strickler J, et al.Induction by E1A oncogene expr
ession of cellular susceptibility to lysis by TNF.Nature,1987,330:581-5
84.
12 Steeg PS,Bevilacqa G,Pozzatti R, et al.Altered expression of nm23,a
gene associated with low tumor metastatic potential,during adenovirus
2 E1A inhibition of experimental metastasis.Cancer Res,1988,48:6550-655
4.
13 Shao RP,Karunagaran D,Zhou BH, et al.Inhibition of nuclear factor-K
B activity is involved in E1A-mediated sensitization ofradiation-induce
d apoptosis.J Biol Chem,1997,272:32739-32742.
14 Xia W,Lan YK,Zhang HZ, et al.Strong correlation between c-erbB-2 ov
erexpression and overall survival of patients with oral squamous cell c
arcinoma.Clin Cancer Res,1997,3:3-9.
15 Hou L,Shi D,Tu SM, et al.Oral cancer progression and c-erbB-2/neu p
roto-oncogene expression.Cancer Letters,1992,65:215-220.
16 Beckhardt RN,Kiyokawa N,Xi L, et al.HER-2/neu oncogene characteriza
tion in head and neck squamous cell carcinoma.Arch Otolaryngol Head Nec
k Surg, 1995, 121:1265-1270.
17 Karja V,Syrjanen S,Kataja V, et al.c-erbB-2 oncogene expression in
salivary land tumors.ORL J Otorhinolaryngol Relat Spec, 1994,56:206-212
.
18 王琪，韩德民，刘鋋，等.头颈部肿瘤的P53基因研究进展.国外医学耳鼻咽喉
科学分册,1996,20：4-7.
19 Liu M,Lawson G,Delos M, et al. Expression of E-cadherin adhesion mo
lecule in vocal cord carcinomas.&nbs
p;Eur Arch Otorhinolaryngol,1997,254:417
-421.
20 王强，郭敏，孙连玉.nm23-H1基因在喉癌组织中表达的研究.中华耳鼻咽喉科
杂志,1996,31：198-200.
21 Yu D,Matin A,Xia W, et al.Liposome-mediated in vivo E1A gene tranfe
r suppressed dissemination of ovarian cancer cells that overexpress HER
-2/neu.Oncogene, 1995,11:1383-1388.
22 Ueno NT,Hung MC,Zhang S, et al.Phase I E1A gene therapy in patients
with advanced breast and ovarian cancer.Proc AACR,1998,39:360-364.
23 Yoo GH,Ensley J,Jacobs J, et al.Intratumoral E1A gene therapy for p
atients with unresectable and recurrent head and neck cancer.Proc AACR,
1998,39:322-324.
24 Kirn D,Nemunaitis J,Ganly I, et al. A phase Ⅱ trial of intratumora
l injection with an E1B-deleted adenovirus, ONYX-015,in patients with r
ecurrent,refractory head and neck cancer.Proc ASCO,1998,17:391-394.
《E1A基因抗癌作用及其在头颈肿瘤治疗中的应用(第3页)》
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