尿毒症病患甲型免疫球蛋白低下的研究
impairment of
IgA production. ELISA revealed positive result in 3 cases of IgAD, which
indicated the presence of IgG type anti-IgA autoantibody. By Flow
cytometry,
decreased numbers of B cell and IgA secreting B cell were detected.
In conclusion, the results showed 1) Serum IgA concentrations were lower
in
both HD and CAPD patients. 2) A higher prevalence of selective IgA
deficiency
in dialysis patients. 3) The clinical symptoms were more obvious in uremic
patients with IgAD, so the deficiency of serum IgA in uremic patients has
the
clinical significance. 4) Decreased serum IgA concentration in uremic
patients
was not related to the dialysis duration, serum creatinine level, and the
existence of hepatitis B or C. 5) Some of the uremic patients with IgAD
were
caused by the existence of circulating anti-IgA autoantibody, but some
were
caused by decrease of the numbers of B cell and IgA secreting B cell,
which
indicate that the mechanisms of IgA deficiency in uremic patients are
diversified.
--------------------------------------------------------------------------------
【 目 录 】
中文摘要------------------------------------------------------ 3
英文摘要-------------------------------------------------------5
第一章 前言------------------------------------------------7
第二章 尿毒症病患血清免疫球蛋白的浓度，及甲型免疫球蛋白缺乏的盛行率------------
----------------------------------------------9
一、 方法及材料------------------------------------------10
二、 结果------------------------------------------------12
第三章 尿毒症病患假型免疫球蛋白低下的临床意义----------------14
一、 尿毒症病患甲型免疫球蛋白低下与感染相关性------------15
二、 唾液的甲型免疫球蛋白的探讨--------------------------17
第四章 尿毒症病患甲型免疫球蛋白低下原因的探讨----------------18
一、 干扰因子的测定--------------------------------------19
二、 自体免疫抗体的侦测----------------------------------20
三、 IgA制造功能的探讨-----------------------------------25
第五章 综合讨论与结论---------------------------------------- 31
参考文献------------------------------------------------------36
表------------------------------------------------------------41
《尿毒症病患甲型免疫球蛋白低下的研究(第2页)》
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