国产盐酸西替利嗪片的人体药代动力学及相对生物利用度
析和双单侧t检验均无显著性差异,且CET片的相对生物利用度为(99.50±8.89)%。■
作者简介:范国荣(1966-),男(汉族),博士,主管药师
范国荣(第二军医大学长海医院药学部,上海200003)
李珍(第二军医大学长海医院药学部,上海200003)
胡晋红(第二军医大学长海医院药学部,上海200003)
石晶(第二军医大学长海医院药学部,上海200003)
沈意翔(第二军医大学长海医院药学部,上海200003)
宋洪杰(第二军医大学长海医院药学部,上海200003)
王卓(第二军医大学长海医院药学部,上海200003)
参考文献
[1]Campoli-RichardsDM,BuckleyMMT,FittonA.Cetirizine:areviewofitspharmacologicalpropertiesandclinicalpotentialinallergicrhinitis,pollen-inducedasthma,andchronicurticaria[J].Drugs,1990,40(5):762-781.
[2]PagliaraA,TestaB,CarruptPA,etal.Molecularpropertiesandpharmacokineticbehaviorofcetirizine,azwitterionicH1-receptorantagonist[J].JMedChem,1998,41(6):853-863.
[3]SpicakV,DabI,HulhovenR,etal.Pharmacokineticsandpharmacodynamicsofcetirizineininfantsandtoddlers[J].ClinPharmacolTher,1997,61(3):325-330.
[4]DesagerJP,DabI,HorsmansY,etal.Apharmacokineticevaluationofthesecond-generationH1-receptorantagonistcetirizineinveryyoungchildren[J].ClinPharmacolTher,1993,53(4):431-435.
[5]LefebvreRA,RosseelMT,BernheimJ.Singledosepharmacokineticsofcetirizineinyoungandelderlyvolunteers[J].IntJClinPharmacolRes,1988,8(6):463-470.
[6]WatsonWTA,SimonsKJ,ChenXY,etal.Cetirizine:apharmacokineticandpharmacodynamicevaluationinchildrenwithseasonalallergicrhinitis[J].JAllergyClinImmunol,1989,84(4):457-464.
[7]HorsmansY,DesagerJP,HulhovenR,etal.Single-dosepharmacokineticsofcetirizineinpatientswithchronicliverdisease[J].JClinPharmacol,1993,33(10):929-932.
[8]PandyaKK,BangaruRA,GandhiTP,etal.High-performancethin-layerchromatographyforthedeterminationofcetirizineinhumanplasmaanditsuseinpharmacokineticstudies[J].JPharmPharmacol,1996,48(5):510-513.
《国产盐酸西替利嗪片的人体药代动力学及相对生物利用度(第3页)》
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作者简介:范国荣(1966-),男(汉族),博士,主管药师
范国荣(第二军医大学长海医院药学部,上海200003)
李珍(第二军医大学长海医院药学部,上海200003)
胡晋红(第二军医大学长海医院药学部,上海200003)
石晶(第二军医大学长海医院药学部,上海200003)
沈意翔(第二军医大学长海医院药学部,上海200003)
宋洪杰(第二军医大学长海医院药学部,上海200003)
王卓(第二军医大学长海医院药学部,上海200003)
参考文献
[1]Campoli-RichardsDM,BuckleyMMT,FittonA.Cetirizine:areviewofitspharmacologicalpropertiesandclinicalpotentialinallergicrhinitis,pollen-inducedasthma,andchronicurticaria[J].Drugs,1990,40(5):762-781.
[2]PagliaraA,TestaB,CarruptPA,etal.Molecularpropertiesandpharmacokineticbehaviorofcetirizine,azwitterionicH1-receptorantagonist[J].JMedChem,1998,41(6):853-863.
[3]SpicakV,DabI,HulhovenR,etal.Pharmacokineticsandpharmacodynamicsofcetirizineininfantsandtoddlers[J].ClinPharmacolTher,1997,61(3):325-330.
[4]DesagerJP,DabI,HorsmansY,etal.Apharmacokineticevaluationofthesecond-generationH1-receptorantagonistcetirizineinveryyoungchildren[J].ClinPharmacolTher,1993,53(4):431-435.
[5]LefebvreRA,RosseelMT,BernheimJ.Singledosepharmacokineticsofcetirizineinyoungandelderlyvolunteers[J].IntJClinPharmacolRes,1988,8(6):463-470.
[6]WatsonWTA,SimonsKJ,ChenXY,etal.Cetirizine:apharmacokineticandpharmacodynamicevaluationinchildrenwithseasonalallergicrhinitis[J].JAllergyClinImmunol,1989,84(4):457-464.
[7]HorsmansY,DesagerJP,HulhovenR,etal.Single-dosepharmacokineticsofcetirizineinpatientswithchronicliverdisease[J].JClinPharmacol,1993,33(10):929-932.
[8]PandyaKK,BangaruRA,GandhiTP,etal.High-performancethin-layerchromatographyforthedeterminationofcetirizineinhumanplasmaanditsuseinpharmacokineticstudies[J].JPharmPharmacol,1996,48(5):510-513.
《国产盐酸西替利嗪片的人体药代动力学及相对生物利用度(第3页)》