奥曲肽治疗消化系内分泌肿瘤进展
时会产生疼痛。冰敷注射部位及让药物恢复至室温可减轻注射疼痛。
9 小结
由于奥曲肽治疗上述消化系统内分泌肿瘤的资料尚不多，尤其是缺乏与现有疗
法的比较、远期效果等资料，故目前尚不能对奥曲肽在这些内分泌瘤治疗中的地位
作出结论性评价。但可以认为，奥曲肽治疗某些不能手术和化疗，或化疗效果差，
目前无良好疗法的消化系统内分泌瘤是合适的。对手术前后控制症状无疑是有益的
。
参考文献
1 Ruszniewski P, Laucournet H, Mignon M, et al. Long-acting somatost
atin(SMS 201-955) in the management of Zollinger-Ellison syndrome: evid
ence for Sustained efficacy. Pancreas，1988；3(2)：145
2 Vinik AL, Lloyd R, Cho K. The use of somatostatin analog in gastro
enteropancreatic tumors other than carcinoid. Metabolism，1990；39(9 su
ppl)：156
3 Mozell EJ, Katz MD, Baxter JN, et al. Long-term efficacy of octreo
tide in the treatment of Zollinger-Ellison Syndrome. Arch Surg，1992；1
27：1019
4 Fluckiger A. Long-term therapy of a metastasizing pancreatic vipom
a using the somatostatin derivative octreotide. Schwei Med Wochenschr，
1992；122：1221
5 Maton PN, Hanks JB, Jekins SA, et al. Use of gut peptide receptor
agonists and antagonists in gastrointestinal disease. Gastroentreol Cli
n North Am，1992；21：551
6 Kvols LK, Becher V, Steer ML. Treatment of the malignant carcinoid
Syndrome. NEJM，1986；315：663
7 Kvols LK. Therapeutic considerations for malignant carcinoid syndr
ome. Acta Oncol，1989；28(3)：433
8 Yinik A, Binder M, Choil TK, et al. Treatment of the carcinoid syn
drome with the somatostatin analogue. Dig Dis Sci，1989；34(1)：14
9 Joensum H, Burroughs AK. Dramatic response of a metastatic careimo
id tumor to a comibnation of interferon and octreotide. Acta Endocrinol
Copenh，1992；126：184
10 Glaser B, Rosler A, Halperin Y. Chronic treatment of a benign ins
ulinoma using the longacting somatostatin
ed Sci，1990；26(1)：16
11 Verschoor L, Uitterlinden P, Lamberts SW, et al. On the use of a
new somatostatin analogue in the treatment of hypoglycaemia in patients
with insulinoma. Chin Endocrinool，1986；25(5)：555
12 Vance ML. Long-term treatment of 18 acromegalic patients with the
somatostatin analog octreotide. Arch In 《奥曲肽治疗消化系内分泌肿瘤进展(第2页)》
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9 小结
由于奥曲肽治疗上述消化系统内分泌肿瘤的资料尚不多，尤其是缺乏与现有疗
法的比较、远期效果等资料，故目前尚不能对奥曲肽在这些内分泌瘤治疗中的地位
作出结论性评价。但可以认为，奥曲肽治疗某些不能手术和化疗，或化疗效果差，
目前无良好疗法的消化系统内分泌瘤是合适的。对手术前后控制症状无疑是有益的
。
参考文献
1 Ruszniewski P, Laucournet H, Mignon M, et al. Long-acting somatost
atin(SMS 201-955) in the management of Zollinger-Ellison syndrome: evid
ence for Sustained efficacy. Pancreas，1988；3(2)：145
2 Vinik AL, Lloyd R, Cho K. The use of somatostatin analog in gastro
enteropancreatic tumors other than carcinoid. Metabolism，1990；39(9 su
ppl)：156
3 Mozell EJ, Katz MD, Baxter JN, et al. Long-term efficacy of octreo
tide in the treatment of Zollinger-Ellison Syndrome. Arch Surg，1992；1
27：1019
4 Fluckiger A. Long-term therapy of a metastasizing pancreatic vipom
a using the somatostatin derivative octreotide. Schwei Med Wochenschr，
1992；122：1221
5 Maton PN, Hanks JB, Jekins SA, et al. Use of gut peptide receptor
agonists and antagonists in gastrointestinal disease. Gastroentreol Cli
n North Am，1992；21：551
6 Kvols LK, Becher V, Steer ML. Treatment of the malignant carcinoid
Syndrome. NEJM，1986；315：663
7 Kvols LK. Therapeutic considerations for malignant carcinoid syndr
ome. Acta Oncol，1989；28(3)：433
8 Yinik A, Binder M, Choil TK, et al. Treatment of the carcinoid syn
drome with the somatostatin analogue. Dig Dis Sci，1989；34(1)：14
9 Joensum H, Burroughs AK. Dramatic response of a metastatic careimo
id tumor to a comibnation of interferon and octreotide. Acta Endocrinol
Copenh，1992；126：184
10 Glaser B, Rosler A, Halperin Y. Chronic treatment of a benign ins
ulinoma using the longacting somatostatin
;analogue SMS 201-955. Isr J M
ed Sci，1990；26(1)：16
11 Verschoor L, Uitterlinden P, Lamberts SW, et al. On the use of a
new somatostatin analogue in the treatment of hypoglycaemia in patients
with insulinoma. Chin Endocrinool，1986；25(5)：555
12 Vance ML. Long-term treatment of 18 acromegalic patients with the
somatostatin analog octreotide. Arch In 《奥曲肽治疗消化系内分泌肿瘤进展(第2页)》
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