成骨细胞骨形成机制研究
组织中产生的调控也与IL-1有相似之处。E2可抑制TNFα的产生，而
1，25(OH)2D3则促进TNFα基因转录，增加TNFα形成［19］。这些全身激素常通过
调控骨组织中的细胞因子产生从而调节骨形成。
除以上局部因子外，其他因子如表皮生长因子(EGF)、TGFα、血小板源性生长
因子(PDGF)及一氧化氮等均对骨形成有明显作用。
参考文献
1 Franklin HE. Bone marrow, cytokines and bone remodeling. N Engl
Med, 1995, 332:305.
2 Zheng MH, Wood DJ, Papadimitrion JM. What′s new in the role of c
ytokines on osteoblast proliferation and differentiation. Pathol Res Pr
act, 1992,188:1104.
3 Thies RS, Bauduy M, Ashton BA, et al. Recombinant human bone morp
hogenetic protein-2 induces osteoblastic differentiation in W-20-17 str
omal cells. Endocrinology, 1992,130:1318.
4 McCabe LR, Last TJ, Lian JB, et al. Expression of cell growth and
bone phenotypic genes during the cell cycle of normal diploid osteobla
sts and osteosarcoma cells. J Cell Biochem, 1994,56:274.
5 Owen TA, Aronow M, Shalhoub V, et al. Progressive development of
the rat osteoblast phenotype in vitro: reciprocal relationships in expr
ession of genes associated with osteoblast proliferation and differenti
ation during formation of the bone extracellular matrix. J Cell Physiol
, 1990,143:420.
6 Jane BJ, Gary SS. Osteoblast biology. In:Robert M, Davd F, Jennif
er K. eds. Osteoporosis. San Diego, California, U.S.A: Academic Press,
1996.23-59.
7 McCabe LR, Kundu BR, Harrison RJ, et al. Developmental expression
and activities of specific fos and jun proteins are functiona
ed to osteoblast maturation: role of Fra-2 and jun D during differentia
tion. Endocrinology, 1996, 137:4398.
8 Lynch MP, Stein GS, Stein L, et al. Apoptosis during in vitro bon
e formation. J Bone Miner Res, 1994,9:S352.
9 Linkhant TA, Mohan S, Baylink DJ. Growth factors for bone growth
and repair: IGF, TGFβ and BMP. Bone, 1996,19:1S.
10 Schmid C, Ernst M. Insulin-like growth factors. In: Maxine G, e
ds. Cytokines and bone metabolism. CRC Press, 1992.229.
11 丁桂芝.类胰岛素生长因子对骨代谢的调节作用.中国骨质疏松杂志，1995
，1：73.
《成骨细胞骨形成机制研究(第3页)》
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1，25(OH)2D3则促进TNFα基因转录，增加TNFα形成［19］。这些全身激素常通过
调控骨组织中的细胞因子产生从而调节骨形成。
除以上局部因子外，其他因子如表皮生长因子(EGF)、TGFα、血小板源性生长
因子(PDGF)及一氧化氮等均对骨形成有明显作用。
参考文献
1 Franklin HE. Bone marrow, cytokines and bone remodeling. N Engl
Med, 1995, 332:305.
2 Zheng MH, Wood DJ, Papadimitrion JM. What′s new in the role of c
ytokines on osteoblast proliferation and differentiation. Pathol Res Pr
act, 1992,188:1104.
3 Thies RS, Bauduy M, Ashton BA, et al. Recombinant human bone morp
hogenetic protein-2 induces osteoblastic differentiation in W-20-17 str
omal cells. Endocrinology, 1992,130:1318.
4 McCabe LR, Last TJ, Lian JB, et al. Expression of cell growth and
bone phenotypic genes during the cell cycle of normal diploid osteobla
sts and osteosarcoma cells. J Cell Biochem, 1994,56:274.
5 Owen TA, Aronow M, Shalhoub V, et al. Progressive development of
the rat osteoblast phenotype in vitro: reciprocal relationships in expr
ession of genes associated with osteoblast proliferation and differenti
ation during formation of the bone extracellular matrix. J Cell Physiol
, 1990,143:420.
6 Jane BJ, Gary SS. Osteoblast biology. In:Robert M, Davd F, Jennif
er K. eds. Osteoporosis. San Diego, California, U.S.A: Academic Press,
1996.23-59.
7 McCabe LR, Kundu BR, Harrison RJ, et al. Developmental expression
and activities of specific fos and jun proteins are functiona
lly relat
ed to osteoblast maturation: role of Fra-2 and jun D during differentia
tion. Endocrinology, 1996, 137:4398.
8 Lynch MP, Stein GS, Stein L, et al. Apoptosis during in vitro bon
e formation. J Bone Miner Res, 1994,9:S352.
9 Linkhant TA, Mohan S, Baylink DJ. Growth factors for bone growth
and repair: IGF, TGFβ and BMP. Bone, 1996,19:1S.
10 Schmid C, Ernst M. Insulin-like growth factors. In: Maxine G, e
ds. Cytokines and bone metabolism. CRC Press, 1992.229.
11 丁桂芝.类胰岛素生长因子对骨代谢的调节作用.中国骨质疏松杂志，1995
，1：73.
《成骨细胞骨形成机制研究(第3页)》
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